Researchers explore possible connection between a widely used drug and dementia risk
Dementia arises from damaged brain cells that can no longer communicate effectively, causing the brain to shrink. Key risk factors include genetics, age, lifestyle, and underlying health conditions.
Gabapentin is an FDA-approved medication for treating nerve pain and seizures. It is also commonly prescribed off-label for issues such as anxiety, insomnia, and sciatica, and is viewed as less addictive than some alternatives.
However, the drug carries potential side effects. These can include dizziness, fatigue, and notably, problems with memory and speech.
A new study has investigated a potential link between gabapentin and dementia. Researchers analyzed health data from over 26,000 adults, comparing those who took the drug with those who did not.
The findings revealed a significant association. Patients with six or more gabapentin prescriptions had a 29% higher risk of dementia and an 85% higher risk of mild cognitive impairment.
The most surprising effect was seen in younger adults aged 35–49. Within this group, the risk of dementia doubled and the risk of mild cognitive impairment tripled.
Study authors and independent experts caution that this research shows a correlation, not proven causation. They highlight the study’s limitations, including a lack of data on other health factors, dosages, and treatment duration. They recommend further investigation and increased vigilance among doctors prescribing the drug long-term.
