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Understanding Large Lumps Under the Skin The skin can signal internal health problems through unusual lumps, especially on the back, shoulders, or arms. While some are harmless, others may require urgent medical attention. Common causes include: 1. Abscesses – Painful, pus-filled infections needing drainage and antibiotics. 2. Sebaceous/Epidermoid Cysts – Usually painless, slow-growing, and benign….